Recombinant Human Dipeptidase 1/DPEP1 Protein (His Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH032356-10, PKSH032356-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: Dipeptidase 1; DPEP1
Target Synonym: Dipeptidase 1; Dehydropeptidase-I; Microsomal Dipeptidase; Renal Dipeptidase; hRDP; DPEP1; MDP; RDP; MBD1
UNIProt ID: P16444
Research Areas: Cell biology; Cancer
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-6His
Accession: P16444
Background: Dipeptidase 1 (DPEP1) is a kidney membrane enzyme that belongs to the peptidase M19 family. DPEP1 is a homodimer and is inhibited by L-penicillamine. DPEP1 hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates. DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics; such as penem and carbapenem. DPEP1 may play an important role in the regulation of leukotriene activity. DPEP1 expression in cancer is significantly higher than that in normal tissue. However; DPEP1 expression decreased with pathological differentiation; lymph-node and distant metastasis.
Sequence: Asp17-Ser385
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 10% glycerol, pH7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 42.1 kDa
Observed MW: 41 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only