Recombinant Human EDNRB/Endothelin B Receptor Protein (Fc Tag) - PKSH030546

Recombinant Human EDNRB/Endothelin B Receptor Protein (Fc Tag)

Size: 100μg

Catalogue Number: PKSH030546-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: EDNRB, Endothelin B Receptor

Target Synonym: ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A

Research Areas: Signal Transduction,

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-mFc

Accession: NP_000106.1

Background: The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. Low EDNRB expression played a role in the progression of ACC tumors. The autosomal recessive mutation in EDNRB may underlie a part of WS1 with the current diagnostic criteria, and supported that Hirschsprung's disease is a multifactorial genetic disease which requires additional factors.

Sequence: Met 1-Lys101

Purity: > 85 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 34.4 kDa

Observed MW: 47.5 and 43.7 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only