Recombinant Human FGF21 Protein (His Tag)
Size: 50μg
Catalogue Number: PKSH031360-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: FGF21
Target Synonym: Fibroblast Growth Factor 21, FGF-21, FGF21
Research Areas: Signal Transduction, Cardiovascular, Cancer,
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His
Accession: NP_061986.1
Background: Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Sequence: His 29-Ser 209
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from 50 mM Tris, 10 % glycerol, 0.05 % Brij 35, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 20.2 kDa
Observed MW: 23 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only