Recombinant Human IFN-alpha B2/IFNA8 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP02885-10, RP02885-20, RP02885-50, RP02885-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human IFN-alpha B2/IFNA8 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Glu189) of Human IFN-alpha B2/IFNA8 (Accession #NP_002161.2) fused with a His tag at the C-terminus.
Alternate Names: IFNA8; IFN-alpha 8; IFNalpha B2; IFN-alpha B2; IFN-alpha-8; IFN-alphaB; interferon alpha type 201; interferon alpha-8; Interferon alpha-B; interferon alpha-B'; Interferon alpha-B2; interferon, alpha 8; LeIF B
SWISS: P32881
GeneID: 3445
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Interferon alpha-B, also known as IFNA8, belongs to the alpha/beta interferon family. Interferons are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They also allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. Interferons also activate immune cells, such as natural killer cells and macrophages. They increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes. They also increase the ability of uninfected host cells to resist new infections by virus. Certain symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Produced by macrophages, IFN-alpha has antiviral activities.
Bio-Activity: Measured in a cell cytotoxicity assay using TF-1 cells. The ED50 for this effect is 0.10‑0.42 ng/mL, corresponding to a specific activity of 2.38×10^6 ~1.0×10^7 units/mg.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Antigen Sequence: SLGCDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE
Endotoxin: < 0.01 EU/μg of the protein by LAL method
Research Use Only