Recombinant Human IL-1 beta Protein
Sizes: 10UG, 20UG, 50UG, 100UG
Catalogue Numbers: RP00002-10, RP00002-20, RP00002-50, RP00002-100
Citations, Manuals and SDS Available upon request.
Description: Recombinant Human IL-1 beta Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala117-Ser269) of human IL-1 beta (Accession #NP_000567.1) fused with an initial Met at the N-terminus and a 6×His tag at the C-terminus.
Background: Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family.This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.
Synonyms: IL-1, IL1-BETA, IL1F2, IL1 beta, IL1B
Swiss-Prot: P01584
GeneID: 3553
Species: Human
Purity: > 95% by SDS-PAGE.
Research Areas: Interleukin, Biosimilar Drug Targets
Expression System: E. coli
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Symbol: IL-1 beta
Storage: Store the lyophilized protein at -20°C to -80 °C for long term.|After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Keywords: Recombinant Human IL-1 beta Protein, IL1B, IL-1, IL1-BETA, IL1F2
Research Use Only