Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active)
Size: 100μg
Catalogue Number: PKSH030736-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: IL17BR; IL17RB
Target Symptom: CRL4; EVI27; IL17BR; IL17RH1
Research Area: Cell biology; Cancer; immunology
Target Species: Human
Expression Host: HEK293 Cells
Application: ELISA
Fusion Tag: C-hFc
Accession: NP_061195.2
Background: IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.
Activity: Immobilized human IL17BR-Fc at 10μg/mL (100μL/well) can bind biotinylated human Fc-IL25.The EC50 of human Fc-IL25 is 4. 5-10.4ng/mL.
Sequence: Met 1-Gly289
Purity: > 85 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 56.9 kDa
Observed MW: 67 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only