Recombinant Human ILT4/LILRB2 protein (His tag)
Sizes: 20μg, 100μg
Catalogue Numbers: PDMH100140-20, PDMH100140-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: ILT4; LILRB2
Target Synonym: Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2; LIR-2; Leukocyte Immunoglobulin-Like Receptor 2; CD85 Antigen-Like Family Member D; Immunoglobulin-Like Transcript 4; ILT-4; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; MIR-10; CD85d; L
UNIProt ID: Q8N423
Research Areas: immunology
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-His
Accession: Q8N423
Background: Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
Sequence: Met1-Val461
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 50.6 kDa
Observed MW: 75 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only