Recombinant Human KEL/CD238 Protein (His Tag)
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH032671-10, PKSH032671-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: KEL; CD238
Target Synonym: Kell blood group glycoprotein; CD238; KEL
UNIProt ID: P23276
Research Areas: Cardiovascular
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-6His
Accession: P23276
Background: Kell blood group glycoprotein (KEL) is a single-pass type II membrane protein which belongs to the peptidase M13 family. It is expressed in Expressed at high levels in erythrocytes and testis, and, at lower levels, in skeletal muscle, tonsils, lymph node, spleen and appendix. KEL has been shown zinc endopeptidase with endothelin-3-converting enzyme activity. It cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. It links via a single disulfide bond to the XK membrane protein that carries the Kx antigen.
Sequence: Asn68-Trp732
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 78.4 kDa
Observed MW: 85-120 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only