Recombinant Human LIMP II/SCARB2/CD36L2 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP00086-10, RP00086-20, RP00086-50, RP00086-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human LIMP II/SCARB2/CD36L2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Arg27-Thr432) of human LIMPII/SR-B2 (Accession #NP_005497.1) fused with an Fc, 6×His tag at the C-terminus.
Alternate Names: AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, SCARB2, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII
SWISS: Q14108
GeneID: 950
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Bio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LDLR/LDL Receptor at 4 μg/mL (100 μL/well) can bind Human SCARB2 with a linear range of 0.016-3.79 μg/mL.
Source: HEK293 cells
Tag: C-hFc&His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Antigen Sequence: RVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILRGETPRVEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIPVLTVIEWSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEILSLIHVFRPDISPYFGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWITDKCNMINGTDGDSFHPLITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTSDNAGFCIPEGNCLGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMINTT
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only