Recombinant Human MANF Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP00044-10, RP00044-20, RP00044-50, RP00044-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human MANF Protein is produced by E. coli expression system. The target protein is expressed with sequence (Leu25-Leu182) of human MANF (Accession #NP_006001.4) fused with an initial Met at the N-terminus and a 6×His tag at the C-terminus.
Alternate Names: MANF, ARMET, ARP
SWISS: P55145
GeneID: 7873
Species: Human
Purity: ≥ 90 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: The protein is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing this protein increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Source: E. coli
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of 20mM PIPES, 500mM NaCl, pH 6.0.Contact us for customized product form or formulation.
Antigen Sequence: LRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASARTDL
Endotoxin: < 1 EU/μg of the protein by LAL method.
Research Use Only