Recombinant Human MCM8 protein (His tag)
Size: 100μg
Catalogue Numbers: PDEH100387-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: MCM8
Target Synonym: DNA helicase MCM8; MCM8; Minichromosome maintenance 8
UNIProt ID: Q9UJA3
Research Areas: Epigenetics and Nuclear signaling
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His & C-His
Accession: Q9UJA3-1
Background: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
Sequence: Met 1-Ser 250
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 27.39 kDa
Observed MW: 35 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only