Recombinant Human METAP1 Protein
Sizes: 10μg, 50μg
Catalogue Numbers: PKSH033589-10, PKSH033589-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: METAP1
Target Symptom: Methionine aminopeptidase 1; MAP 1; MetAP 1; Peptidase M 1; METAP1; MAP1A; MetAP1A
Research Area: Signal Transduction; metabolism;
Target Species: Human
Expression Host: E.coli
Fusion Tag: None
UNIProt ID: P53582
Accession: P53582
Background: Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.
Sequence: Met1-Phe386
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10%glycerol, pH8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 43.2 kDa
Observed MW: 38&45-50 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only