Recombinant Human SPEG/APEG-1 Protein (His Tag)
Size: 50μg
Catalogue Number: PKSH030334-50
Citations, Manuals and MSDS Available upon request.
Abbreviation: SPEG, APEG-1
Target Synonym: APEG-1, APEG1, BPEG, CNM5, SPEGalpha, SPEGbeta
UNIProt ID: Q15772
Target Species: Human
Expression Host: E.coli
Fusion Tag: C-His
Accession: Q15772-4
Background: Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein which belongs to theprotein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains twofibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform1of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform3of SPEG is predominantly expressed in the aorta. Isoform3of SPEG appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC. Isoform3of SPEG may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Isoform3of SPEG is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.
Sequence: Met 1-Glu 113
Purity: > 85 % as determined by reducing SDS-PAGE.
Formulation: Supplied as sterile solution of PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: Please contact us for more information.
Calculated MW: 14 kDa
Observed MW: 19 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only