Recombinant Human Tissue-type plasminogen activator/TPA/PLAT Protein - RP00595

Recombinant Human Tissue-type plasminogen activator/TPA/PLAT Protein

Sizes: 10ug, 50ug

Catalogue Number: RP00595-10, RP00595-50

Citations, Manuals and MSDS Available upon request.

Description: Recombinant Human Tissue-type plasminogen activator/TPA/PLAT Protein is produced by Human cells expression system. The target protein is expressed with sequence (Ser36-Pro562) of Human Tissue-type plasminogen activator/TPA/PLAT (Accession #P00750) fused with a 6×His tag at the C-terminus.

Alternate Names: PLAT, T-PA, TPA, TPA

SWISS: P00750

GeneID: 5327

Species: Human

Purity: ≥ 95 % as determined by SDS-PAGE.

Storage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.

Background: Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains:EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs to the peptidase S1family. The main function of this protein is to convert plasminogen into biologically active plasmin. As a protease, PLATplays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulatingthe post-translational activation of growth factors. PLAT is found not only in the blood, where its primary function is as athrombolytic enzyme, but also in the central nervous system (CNS). It participates in a number of physiological andpathological events in the CNS, as well as the role of neuroserpin as the natural regulator of PLAT's activity in theseprocesses. Increased or decreased activity of PLAT leads to hyperfibrinolysis or hypofibrinolysis, respectively. In addition, asa cytokine, PLAT plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. Thus, as afibrogenic cytokine, it promotes the progression of kidney diseases.

Source: HEK293 cells

Tag: C-6×His

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM MES,150mM NaCl,0.2mM CaCl2, pH5.5. Contact us for customized product form or formulation.

Antigen Sequence: SYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP

Endotoxin: < 1 EU/μg of the protein by LAL method.

Research Use Only