Recombinant Human TNFRSF25/DR3 Protein (aa 1-199, Fc Tag)
Size: 100μg
Catalogue Number: PKSH030905-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: TNFRSF25, DR3
Target Synonym: Tumor necrosis factor receptor superfamily member 25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, TNFRSF25, Protein WSL-1, LARD, Protein WSL, Lymphocyte-associated receptor of death, Death receptor 3, Apoptosis-mediating receptor TRAMP, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apo-3
Research Areas: Signal Transduction, Cell biology,
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-hFc
Accession: NP_003781.1
Background: Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this TNFRSF25 encoding gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Sequence: Met 1-Gln 199
Purity: > 96 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 46 kDa
Observed MW: 55 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only