Recombinant human Trk-A/NTRK1 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP01726-10, RP01726-20, RP01726-50, RP01726-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant human Trk-A/NTRK1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala33-Glu413) of human Trk-A/NTRK1 (Accession #NP_001012331.1) fused with and a 6×His tag at the C-terminus.
Alternate Names: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; NTRK1
SWISS: P04629-1
GeneID: 4914
Species: human
Purity: ≥ 90 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: This protein is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Bio-Activity: Measured by its ability to inhibit NGF-induced proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.086-0.34 µg/mL in the presence of 10 ng/mL of Recombinant Human beta-NGF.
Source: HEK293 cells
Tag: C-6His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Antigen Sequence: AAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDE
Endotoxin: < 0.01 EU/μg of the protein by LAL method
Research Use Only