Recombinant Human Trk-C/NTRK3 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP00222-10, RP00222-20, RP00222-50, RP00222-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human Trk-C/NTRK3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys32-Asp428) of human TrkC/NTRK3 (Accession #NP_001012338.1) fused with a 6×His tag at the C-terminus.
Alternate Names: NTRK3, GP145-TrkC, TRKC, gp145(trkC)
SWISS: Q16288
GeneID: 4916
Species: Human
Purity: ≥ 90 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
Bio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human NTF3 at 2 μg/mL (100 μL/well) can bind Recombinant human TrkC with a linear range of 231-925 ng/mL.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Antigen Sequence: CPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEED
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only