Recombinant Human WISP1 protein (His tag) - PDMH100090

Recombinant Human WISP1 protein (His tag)

Sizes: 20μg, 100μg

Catalogue Numbers: PDMH100090-20, PDMH100090-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: WISP1

Target Synonym: CCN family member 4; WNT1-inducible-signaling pathway protein 1; WISP-1; Wnt-1-induced secreted protein; WISP1; CCN4

UNIProt ID: O95388

Research Areas: Epigenetics and Nuclear Signaling

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

Accession: O95388

Background: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.

Sequence: Met1-Asn367

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: Please contact us for more information.

Calculated MW: 40.26 kDa

Observed MW: 60 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only