Recombinant Mouse CXCL2/MIP-2 Protein
Sizes: 20μg, 100μg
Catalogue Numbers: PKSM040996-20, PKSM040996-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: CXCL2; MIP-2
Target Synonym: MIP-2; chemokine ligand 2; C-X-C motif chemokine 2; GRO beta; GRO2; GROB; Gro-beta; Growth-regulated protein beta; Macrophage Inflammatory Protein-2-alpha; melanoma growth stimulatory activity beta; cxcl2; MGSA-b; MGSA-beta; MIP2A; MIP2-alpha; SCYB2.
UNIProt ID: P10889
Target Species: Mouse
Expression Host: E.coli
Fusion Tag: None
Accession: P10889
Background: C-X-C motif chemokine 2 (CXCL2, MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.
Sequence: Ala28-Asn100
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 7.9 kDa
Observed MW: 10 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only