Recombinant Mouse DKK1 protein (His tag)
Sizes: 20μg, 100μg
Catalogue Numbers: PDMM100011-20, PDMM100011-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: DKK1
Target Synonym: Dickkopf-related protein 1; Dickkopf-1; Dkk-1; mDkk-1; Dkk1
UNIProt ID: O54908
Research Areas: Immunology
Target Species: Mouse
Expression Host: HEK293 Cells
Fusion Tag: C-His
Accession: O54908
Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning.
Sequence: Met1-His272
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 29.81 kDa
Observed MW: 40 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only