Recombinant Mouse IL-23 Receptor/IL-23R Protein (Fc Tag) - PKSM041055

Recombinant Mouse IL-23 Receptor/IL-23R Protein (Fc Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSM041055-10, PKSM041055-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: IL-23 Receptor; IL-23R

Target Synonym: Interleukin-23 receptor; Il23r; IL-23 receptor; IL-23R; interleukin 23 receptor

UNIProt ID: Q8K4B4

Target Species: Mouse

Expression Host: HEK293 Cells

Fusion Tag: C-Fc

Accession: Q8K4B4

Background: Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.

Sequence: Gly24-Asp372

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 67.3 kDa

Observed MW: 90-110 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only