Recombinant Mouse IL1RL1/ST2 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP01673-10, RP01673-20, RP01673-50, RP01673-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Mouse IL1RL1/ST2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ala332) of mouse IL1RL1 (Accession #NP_001020773.1) fused with and a hFc tag at the C-terminus.
Alternate Names: T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1; IL1RL1
SWISS: P14719
GeneID: 17082
Species: Mouse
Purity: ≥ 90 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.
Bio-Activity: Measured by its binding ability in a functional ELISA. Immobilized mouse IL-33 (Catalog: RP01802) at 10 μg/mL (100 μL/well) can bind mouse IL1RL1 (Catalog: RP01673) with a linear range of 19.5-1197.7 ng/mL.
Source: HEK293 cells
Tag: C-hFc
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Antigen Sequence: SKSSWGLENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRSPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPIDHR
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only