Recombinant Mouse KYNU/Kynureninase Protein (His Tag)(Active)
Size: 100μg
Catalogue Number: PKSM040748-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: KYNU; Kynureninase
Target Symptom: 4432411A05Rik
Target Species: Mouse
Expression Host: Baculovirus-Insect Cells
Application: Enzyme
Fusion Tag: C-His
UNIProt ID: Q9CXF0
Accession: Q9CXF0
Background: Genetic studies in mouse and human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population.The results show that the rare KYNU variant Arg188Gln affects kynureninase activity and are consistent with the hypothesis that this mutation can predispose to essential hypertension.
Activity: Measured by its ability to oxidize 3-hydroxykynurenine. The specific activity is > 100 pmoles/min/μg.
Sequence: Met 1-Ser 464
Purity: > 94 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 53.7 kDa
Observed MW: 47 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only