Recombinant Mouse TNFRSF13C/BAFFR/CD268 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP01493-10, RP01493-20, RP01493-50, RP01493-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Mouse TNFRSF13C/BAFFR/CD268 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser10-Ala71) of mouse BAFFR/TNFRSF13C (Accession #NP_082351.1) fused with a Fc, Avi tag at the C-terminus.
Alternate Names: Bcmd, Baffr, Bcmd1, BAFF-R, Bcmd-1, Lvis22, TNFRSF13C
SWISS: Q9D8D0
GeneID: 72049
Species: Mouse
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
Bio-Activity: Measured by its binding ability in a functional ELISA.Immobilized Human TNFSF13B (Catalog: RP00018) at 2 μg/mL (100 μL/well) can bind Mouse TNFRSF13C (Catalog: RP01493) with a linear range of 0.001-5.3 ng/mL.
Source: HEK293 cells
Tag: C-hFc&Avi
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Antigen Sequence: SQRSRDSSVPTQCNQTECFDPLVRNCVSCELFHTPDTGHTSSLEPGTALQPQEGSALRPDVA
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only