Recombinant Mouse Wnt Inhibitory Factor 1/WIF1 Protein (His Tag) - PKSM040406

Recombinant Mouse Wnt Inhibitory Factor 1/WIF1 Protein (His Tag)

Size: 100μg

Catalogue Number: PKSM040406-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: Wnt Inhibitory Factor 1, WIF1

Target Synonym: AW107799, WIF-1

UNIProt ID: Q9WUA1

Target Species: Mouse

Expression Host: HEK293 Cells

Fusion Tag: C-His

Accession: Q9WUA1

Background: WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein which binds WNT proteins and inhibits their activities. It contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 may be involved in mesoderm segmentation and can be detected in fish, amphibia and mammals. WIF-1 is a recurrent target in human salivary gland oncogenesis. Downregulation of WIF1 takes part in the development and progression of pleomorphic adenomas. WIF1 also is a tumor suppressor, and has been found to be epigenetically silenced in various cancers, specifically in nonfunctioning pituitary tumors. WIF1 are expected to have molecular function (protein tyrosine kinase activity) and to localize in various compartments (extracellular space, extracellular region).

Sequence: Met1-Trp379

Purity: > 93 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 39.8 kDa

Observed MW: 44 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only