Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81487-50, E-AB-81487-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: Transcription Factor 7 Like 2
Target Synonym: TCF7L2; HMG box transcription factor 4; HTCF-4; T-cell factor-4 variant X2; T-cell factor 4; Transcription factor 7-like 2; TCF-4
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: WB, IHC-P
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R09-1D1
UNIProt ID: Q9NQB0
Background: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.
Concentration: 300 μg/mL
Immunogen: A synthetic peptide of human TCF-4
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:500-1:1000 IHC 1:50-1:100
Calculated MW: 68kDa
Observed MW: 68kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only