Product Description

RECQL4 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60115-50, BS60115-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: In humans, the RecQ helicase family includes WRN, BLM, RecQL1, RecQL4 and RecQL5 proteins, all of which contain a conserved helicase domain. WRN and BLM have been demonstrated to be the responsible genes in Werner and Bloom syndromes, respectively. RecQL1 and RecQL5 also belong to the human RecQ helicase family, but their correlation with genetic disorders, if any, is unknown. The gene encoding human RecQL4, which maps to chromosome 8q24.3, is believed to be the gene responsible for the development of Rothmund-Thomson syndrome (RTS). The levels of WRN, BLM, RecQL1, 4 and 5 are differentially up-regμlated to guarantee genomic stability in cells that are transformed or actively proliferating. In humans, RecQL1 and RecQL5 map to chromosome 12p12 and 17q25, respectively.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: ATP-dependent DNA helicase Q4, DNA helicase, RecQ-like type 4, RecQ4, RTS, RecQ protein-like 4, RECQ4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human RECQL4.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: RECQL4 polyclonal antibody detects endogenous levels of RECQL4 protein.

Molecular Weight: ~ 133 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O94761

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only