Renin (L238) Polyclonal Antibody-BS3925

Renin (L238) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3925-50, BS3925-100

Sizes: 50µl, 100µl

Swiss-Prot: P00797

Host: Rabbit

Reactivity: Human

Applications: WB, IHC

Background: Renin is a highly specific endopeptidase that mediates the cleavage of the circulating substrate angiotensinogen to yield Angiotensin I. Angiotensin-converting enzyme I (ACE) then completes the conversion from Angiotensin I to Angiotensin II which is significant in the regulation of electrolyte balance and blood pressure. Sympathetic stimulation (β1-adrenergic receptors), renal artery hypotension and decreases in sodium delivery to the distal tubules of the kidney signal the release of Renin. The Renin-Angiotensin system (RAS) is essential for regulating blood volume, arterial pressure and normal cardiac and vascular function. Renin is synthesized and secreted by modified smooth muscle cells in the juxtaglomerular apparatus (JGA) of the kidney. Expression of Renin in other tissues, including brain, has been verified although the homeostatic role it may play is yet to be firmly established.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Renin (L238) polyclonal antibody detects endogenous levels of Renin protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Renin (L238) polyclonal antibody at 1:1000 dilution
Lane 1: THP-1 whole cell lysate (37ug) Lane 2: JURKAT whole cell lysate (37ug) , Immunohistochemistry (IHC) analyzes of Renin (L238) pAb in paraffin-embedded human placenta tissue.

Bioworld Molecular Weight: ~ 45 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; FLJ10761; HNFJ2; REN; Ren1; RENI; Renin; Renin precursor renal

Immunogen: Synthetic peptide, corresponding to amino acids 211-260 of Human Renin.

Conjugate: Unconjugated

Modification: Unmodified