Renin Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A1585-20, A1585-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.
Synonyms: RTD; HNFJ2; ADTKD4; Renin
GeneID: 5972
Swiss-Prot: P00797
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 45kDa
Observed Molecular Weight: 46kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-406 of human Renin (NP_000528.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Research Areas: Cardiovascular, Blood
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:100 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Membrane, Secreted
Positive Samples: Mouse kidney, Rat kidney
Keywords: 5972, sc-27318, sc-22752, Angiotensinogenase, REN, Renin, HNFJ2, renin, angiotensin-forming enzyme, angiotensinogenase, renin precursor, renal, P00797, Angiotensin-Forming Enzyme, Renin Precursor, Renal, EC 3.4.23.15, FLJ10761, sc27318, sc 27318, sc22752, sc 22752
Symbol: REN
Category: Polyclonal Antibodies
Research Use Only