Product Description

Renin Receptor Polyclonal Antibody

Catalogue Numbers: BS5887-50, BS5887-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O75787

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The Renin Receptor, also known as ATP6AP2 (ATPase H+-transporting lysosomal accessory protein 2), ATP6IP2 (ATPase H+-transporting lysosomal-interacting protein 2), CAPER or M8-9, is an ATPase-associated protein that functions as a Renin and prorenin cellular receptor. Expressed in the brain, heart, liver, kidney, placenta and pancreas, the Renin Receptor functions to activate ERK 1 and ERK 2, thereby mediating Renin-dependent cellular responses. The Renin Receptor has a subunit that associates with the transmembrane domain of V-type ATPases and interacts with Renin. These interactions increase the catalytic activity of Renin in the Renin-Angiotensin system (RAS), thus upregulating the conversion of angiotensinogen to Angiotensin.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Renin Receptor polyclonal antibody detects endogenous levels of Renin Receptor protein.

Extra Notes: Western blot (WB) analysis of ATP6AP2 pAb at 1:500 dilution
Lane1:THP-1 whole cell lysate(40ug)
Lane2:HEK293T whole cell lysate(40ug)
Lane3:Hela whole cell lysate(40ug)
Lane4:CT-26 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 43kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10
N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit; ATP6AP2; ATP6IP2; CAPER; ELDF10; HT028; MSTP009; PSEC0072

Immunogen: Synthetic peptide, corresponding to amino acids 209-254 of Human Renin Receptor.

Conjugate: Unconjugated

Modification: Unmodified