Rev-erbα (phospho-Ser55/59) rabbit pAb - ES13420

Rev-erbα (phospho-Ser55/59) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES13420-50, ES13420-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013],

Alternate Name: Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized phosho peptide around human Rev-erbα (Ser55 and 59)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 67kD

Human Gene ID: 9572

Human SWISS Prot NO: P20393

Subcellular Location: Nucleus. Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20. Phosphorylation by CSNK1E enhances its cytoplasmic localization.

Research Use Only