RFOX1 Polyclonal Antibody - BT-AP13684

RFOX1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13684-20, BT-AP13684-50, BT-AP13684-100

Citations, Manuals and MSDS Available upon request.

Background: The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Developmental biology; Epigenetics and nuclear signaling; Neuroscience

Target Protein: RBFOX1

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: RNA binding protein fox-1 homolog 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9NWB1; Mouse: Q9JJ43

Synonyms: RNA binding protein fox-1 homolog 1;Ataxin-2-binding protein 1;Fox-1 homolog A;Hexaribonucleotide-binding protein 1

GeneID: Human: 54715

Research Use Only