Product Description

RHEB Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS91168-50, BS91168-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: H-, K- and N-Ras represent the prototype members of a family of small G proteins which are frequently activated to an oncogenic state in a wide variety of human tumors. Activation is due to point mutations at position 12 or 61 within their coding sequence. Such mutations cause these proteins to be constitutively converted to their active GTP-bound rather than the inactive GDP-bound state. The related human R-Ras gene was initially cloned by low stringency hybridization methods. Position 38 or 87 mutants of R-Ras (analogous to positions 12 and 61 in H-Ras) have been shown to be capable of activating oncogenic function. Ras p21 in its active GTP binding state binds to Raf-1, resμlting in activation of the MAP kinase signaling cascade. An additional member of the Ras family, Rheb (Ras-related GTP-binding protein), also interacts with Raf-1. This interaction is potentiated by growth factors and agents that increase cAMP levels.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, ICC, IF, IHC, FC

Alternate Names: RHEB, RHEB2, Ras homolog enriched in brain 2, formerly, GTP binding protein Rheb, GTP-binding protein Rheb, MGC111559, Ras homolog enriched in brain 2, Ras homolog enriched in brain, RHEB 2, Rheb, RHEB, RHEB2, RHEB2, formerly,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: A synthetic peptide of human RHEB.

Dilution: WB:1:1000-1:5, 000
IF/ICC:1:20-1:50
IHC:1:20-1:100
FC:1:20-1:100

Purification: ProA affinity purified

Specificity: RHEB polyclonal antibody detects endogenous levels of RHEB protein.

Molecular Weight: 21 kDa

Pathway: MTOR signaling,

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

SwissProt: Q15382

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only