RhoBTB1/2 (T85) Polyclonal Antibody-BS2503

RhoBTB1/2 (T85) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS2503-50, BS2503-100

Sizes: 50µl, 100µl

Swiss-Prot: Q9BYZ6/O94844

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: RHOBTB1 (Rho-related BTB domain-containing protein 1) and RHOBTB3 (Rho-related BTB domain-containing protein 3) each contain two BTB (POZ) domains and belong to the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. While both RHOBTB1 and RHOBTB3 are expressed ubiquitously, RHOBTB1 is found at high levels in placenta, stomach, testis, kidney and skeletal muscle, whereas RHOBTB3 is found at high levels in neural and cardiac tissues. RHOBTB1 is thought to play a role in GTPase-mediated signaling and may participate in organization of the Actin filament system. Additionally, RHOBTB1 expression is decreased in head and neck carcinomas, suggesting a possible role for RHOBTB1 as a tumor suppressor.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: RhoBTB1/2 (T85) polyclonal antibody detects endogenous levels of RhoBTB1/2 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of RhoBTB1/2 (T85) pAb at 1:1000 dilution
Lane 1: The Kidney tissue lysate of Mouse (40ug)
Lane 2: The Kidney tissue lysate of Rat (40ug)
Lane 3: U-87MG whole cell lysate (40ug)
Lane 4: Hela whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of RhoBTB1/2 (T85) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 83 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Rho-related BTB domain-containing protein 2; Deleted in breast cancer 2 gene protein; p83; RHOBTB2; DBC2; KIAA0717; Rho-related BTB domain-containing protein 1; RHOBTB1; KIAA0740

Immunogen: Synthetic peptide, corresponding to amino acids 52-98 of Human RhoBTB1.

Conjugate: Unconjugated

Modification: Unmodified