Rhotekin Polyclonal Antibody - BT-AP07840

Rhotekin Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07840-20, BT-AP07840-50, BT-AP07840-100

Citations, Manuals and MSDS Available upon request.

Background: RTKN (rhotekin) encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Areas: Signal Transduction

Target Protein: RTKN

Applications: IHC-p, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Rhotekin Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 62667

UniProt Accession: Human: Q9BST9; Mouse: Q8C6B2; Rat: Q6V7V2

Synonyms: RTKN; RTKN1; Rhotekin

GeneID: Human: 6242; Mouse: 20166; Rat: 297383

Research Use Only