Ribosomal Protein S6 Polyclonal Antibody - BT-AP07893

Ribosomal Protein S6 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07893-20, BT-AP07893-50, BT-AP07893-100

Citations, Manuals and MSDS Available upon request.

Background: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPS6 encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. 40S ribosomal protein S6 belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: RPS6

Applications: WB, IF, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Ribosomal Protein S6 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 28681

UniProt Accession: Human: P62753; Mouse: P62754; Rat: P62755

Synonyms: RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33

GeneID: Human: 6194; Mouse: 20104; Rat: 1.00911e+008

Research Use Only