RLN3 Polyclonal Antibody
Catalogue Numbers: BS60503-50, BS60503-100
Sizes: 50µl, 100µl
Alternative Name: Relaxin-3; Insulin-like peptide INSL7; Insulin-like peptide 7; Prorelaxin H3; RLN3; INSL7, RXN3, ZINS4; UNQ6188; PRO20213
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q8WXF3
Host: Rabbit
Reactivity: Human, Mouse
Applications: WB
All Applications: WB: 1:500~1:1000
Background: Relaxin 3 is part of the Relaxin-like peptide family that plays an important
neuropeptide signaling role. Relaxin 3 is a ligand for two structurally related G protein-coupled receptors, human Relaxin receptor 3 and Relaxin receptor 4. The greatest levels of Relaxin 3 expression occur in the brain, specifically in the pons/medulla, with highest levels in the pars ventromedialis of the dorsal tegmental nucleus and with lower levels in the hippocampus and olfactory regions. Significant expression is also observed in the spleen, thymus, lung and ovary. Relaxin 3 inhibits Forskolin-stimulated cAMP accumulation in a dose-dependent manner in cells that express Relaxin receptor 3. Acute and repeated administration of Relaxin 3 causes a decrease in levels of the plasma
thyroid stimulating hormone, suggesting that Relaxin 3 may play a role in
long-term control of food intake.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: RLN3 polyclonal antibody detects endogenous levels of RLN3 protein.
Bioworld Molecular Weight: ~ 15 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of RLN3 polyclonal antibody at 1:500 dilution
Lane 1: Hela whole cell lysate
Lane 2: HEK293T whole cell lysate
Lane 3: Raw264.7 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human RLN3.
Conjugate: Unconjugated
Modification: Unmodified