Product Description

RNF111 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61642-50, BS61642-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. The early mammalian embryo is patterned by signals emanating from extraembryonic and embryonic signaling centers, most notably the anterior visceral endoderm (AVE) and the node, respectively. Nodal-related members of the transforming growth factor (TGF) β family regμlate the induction of mesoderm, endoderm and mesendoderm. The different tissues form in response to the same signaling molecμles, which may elicit differential responses through concentration-dependent effects, extracellμlar cofactors and antagonists, or factor potentiation. The nuclear protein Arkadia specifically potentiates the mesendoderm-inducing activity of a subset of TGFβ family members and interacts with Nodal, which mediates the function of Arkadia in node induction. Arkadia functions within extraembryonic tissues and is required to induce the node as an essential modμlator of the nodal signalling cascade.The human gene for Arkadia maps to chromosome 15q21 and encodes a 441 amino acid protein. The murine gene for Arkadia maps to chromosome 9 39.0 cM and encodes a 989 amino acid protein.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: E3 ubiquitin-protein ligase Arkadia, RING finger protein 111, hRNF111, RING-type E3 ubiquitin transferase Arkadia, RNF111

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding Human RNF111.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: RNF111 polyclonal antibody detects endogenous levels of RNF111 protein.

Molecular Weight: ~ 120 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q6ZNA4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only