Product Description

RNGTT Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8211-50, BS8211-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: RNGTT (RNA guanylyltransferase and 5'-phosphatase), also known as HCE, HCE1, hCAP or CAP1A, is a 597 amino acid protein that localizes to the nucleus and exists as four alternatively spliced isoforms. Expressed in kidney, lung, heart, brain, liver, testis, skin and muscle, RNGTT acts as a bifunctional mRNA-capping enzyme that exhibits RNA 5'-triphosphatase activity at its N-terminus and mRNA guanylyltransferase activity at its C-terminus. Via its catalytic activity, RNGTT facilitates the first two steps of mRNA cap formation, naming the removal of a γ-phosphate from the end of nascent mRNA and the subsequent transfer of the phospho residue to the 5’-diphosphate terminus. The gene encoding RNGTT maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF

Alternate Names: mRNA-capping enzyme, HCAP1, HCE, RNGTT, CAP1A

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human RNGTT.

Dilution: WB: 1:500~1:2000
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: RNGTT polyclonal antibody detects endogenous levels of RNGTT protein.

Molecular Weight: ~ 69 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60942

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only