RO60 rabbit pAb - ES7287

RO60 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7287-50, ES7287-100

Citations, Manuals and MSDS Available upon request.

Background: disease:Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign., function:RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the Ro 60 kDa family., similarity:Contains 1 TROVE domain., subunit:Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.,

Alternate Name: TROVE2; RO60; SSA2; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; Ro 60 kDa autoantigen; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; SS-A; TROVE domain family member 2

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human TROVE2. AA range:311-360

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 70kD

Human Gene ID: 6738

Human SWISS Prot NO: P10155

Subcellular Location: Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Research Use Only