ROM-K (phospho Ser44) rabbit pAb - ES6002

ROM-K (phospho Ser44) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6002-50, ES6002-100

Citations, Manuals and MSDS Available upon request.

Background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Alternate Name: KCNJ1; ROMK1; ATP-sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K; Inward rectifier K (+) channel Kir1.1; Potassium channel; inwardly rectifying subfamily J member 1

Source: Rabbit

Applications: IHC; IF; ELISA

Dilution: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human ROMK/Kir1.1 around the phosphorylation site of Ser44/25. AA range:11-60

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 3758

Human SWISS Prot NO: P48048

Subcellular Location: Cell membrane; Multi-pass membrane protein. Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane.

Research Use Only