RPA32/RPA2 Mouse Monoclonal Antibody - RA11952

RPA32/RPA2 Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA11952-50, RA11952-100

Citations, Manuals and MSDS Available upon request.

Background: function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis) . Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB; IP; ICC

Species Cross-Reactivity: Human

GeneID (Human): 6118

Protein MW (KDa): 32

SWISS: P15927

Source: Mouse

Research Use Only