Product Description

RPGF4 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13915-20, BT-AP13915-50, BT-AP13915-100

Citations, Manuals and MSDS Available upon request.

Background: The DEP domain is involved in membrane localization independent from regulation by cAMP.,The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.,Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.,Contains 1 DEP domain.,Contains 1 N-terminal Ras-GEF domain.,Contains 1 Ras-GEF domain.,Contains 2 cyclic nucleotide-binding domains.,subunit:Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.,tissue specificity:Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.,

Research Areas: Signal transduction

Target Protein: RAPGEF4

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Rap guanine nucleotide exchange factor 4

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q8WZA2; Mouse: Q9EQZ6; Rat: Q9Z1C7

Synonyms: Rap guanine nucleotide exchange factor 4;Exchange factor directly activated by cAMP 2;Exchange protein directly activated by cAMP 2;EPAC 2;cAMP-regulated guanine nucleotide exchange factor II

GeneID: Human: 11069

Research Use Only