Product Description

RREB1 (E597) Polyclonal Antibody

Catalogue Numbers:BS9158-50, BS9158-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q92766

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC

All Applications: WB: 1:500~1:1000
IHC: 1:50~1:200

Background: RREB1 (Ras responsive element binding protein 1), also known as FINB, LZ321 or Zep-1, is a 1,687 amino acid protein that localizes to nuclear speckles and contains fifteen C2H2-type zinc fingers. Expressed in pancreas, heart, liver, placenta, lung, kidney and skeletal muscle, RREB1 functions as a transcription factor that binds to the Ras-responsive element (RRE) of target gene promotors, thereby inducing their transcription. In addition, RREB1 is thought to be involved in Raf/Ras-mediated cell differentiation, possibly by enhancing the expression of Calcitonin, a hormone that is produced by the thyroid gland and plays an essential role in maintaining blood calcium levels. Due to its involvement in cell differentiation events, RREB1 may be involved in Raf/Rasrelated tumor formation. Four isoforms of RREB1 exist due to alternative splicing.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~ 181 kDa

Specificity: RREB1 (E597) polyclonal antibody detects endogenous levels of RREB1 protein.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: FINB; Finger protein in nuclear bodies; Hindsight homolog; HNT; LZ321; Raf responsive zinc finger protein LZ321; Raf-responsive zinc finger protein LZ321; RAS responsive element binding protein 1; Ras-responsive element-binding protein 1; RREB 1; RREB-1; Rreb1; RREB1; Zep 1; Zep-1; Zep1; Zinc finger motif enhancer binding protein 1; Zinc finger motif enhancer-binding protein 1;

Immunogen: Synthetic peptide, corresponding to amino acids 560-610 of Human RREB1.

Conjugate: Unconjugated

Modification: Unmodified