RUBIC Rabbit Polyclonal Antibody - BT-AP12356

RUBIC Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12356-20, BT-AP12356-50, BT-AP12356-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains| an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling| and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Research Areas: Cancer; Cardiovascular; Cell biology; Metabolism

Target Protein: KIAA0226

Applications: WB

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: RUBIC

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q92622; Mouse: Q80U62

Synonyms: RUBIC; Run domain Beclin-1 interacting and cystein-rich containing protein; Rubicon; Beclin-1 associated RUN domain containing protein; Baron

GeneID: Human: 9711; Mouse: 100502698

Research Use Only