Product Description

RYR1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91190-50, BS91190-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P21817(Human) E9PZQ0(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: DotBlot IHC FC

All Applications: DotBlot:1:500-1:1,000
IHC:1:50-1:200
FC:1:50-1:100

Background: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.

Purification and Purity: Peptide affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: RYR1 polyclonal antibody detects endogenous levels of RYR1 protein.

Bioworld Molecular Weight: 565 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Dot blot analysis of anti-RYR1 immunization peptide on PVDF. 1ug, 2ug and 4ug peptides were given in this test. Anti-RYR1 antibody was diluted with 1/500., Immunohistochemical analysis of paraffin-embedded human fetal skeletal muscle tissue using anti-RYR1 antibody. Counter stained with hematoxylin.

Alternative Name: RYR-1, RyR1, RYR1, RYDR, Arrhythmogenic right ventricular dysplasia 2, ARVC2, ARVD2, Brain ryanodine receptor calcium release channel, Brain type ryanodine receptor, Cardiac muscle ryanodine receptor calcium release channel, Cardiac muscle type ryanodine receptor, CCO, Central core disease of muscle, HBRR, hRYR 2, hRYR2, MHS, MHS1, Ryanodine receptor 1 (skeletal), Ryanodine receptor 1, Ryanodine receptor 2 (cardiac), Ryanodine receptor 2, Ryanodine receptor 3, Ryanodine receptor type1, RYDR, RYR 1, RYR 2, RYR 3, RYR, RYR-1, RyR1, RYR1, RYR2, RYR3, Sarcoplasmic reticulum calcium release channel, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle type ryanodine receptor, Skeletal muscle-type ryanodine receptor, SKRR, Type 1 like ryanodine receptor, Type 1 ryanodine receptor, VTSIP,

Immunogen: Synthetic peptide within human RYR1 aa 1350-1400.

Conjugate: Unconjugated

Modification: Unmodified