Product Description

S100A8 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS80263-50, BS80263-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regμlation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9 which has a wide plethora of intra- and extracellμlar functions. The intracellμlar functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modμlation of the tubμlin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellμlar functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.

Category: Primary Antibody

Reactivity: Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: p, Ca, MR, p8, B8A, CFA, B8Ag, CFAg, CP-1, Caga, MRP8, 60B8A, CP-10, 60B8Ag, AI323541

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of mouse S100A8(NP_038678.1).

Dilution: WB, 1:500 - 1:2000 IHC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 11KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P27005

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only