S100B Monoclonal Antibody - BT-MCA2363

S100B Monoclonal Antibody Sizes: 50μL, 100μL Catalogue Number: BT-MCA2363-50, BT-MCA2363-100 Citations, Manuals and MSDS Available upon request. Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Research Areas: Cell Biology, Signal Transduction, Epigenetics and Nuclear Signaling, Stem Cells Target Protein: S100B Applications: WB, FCM Reactivity: Human Clonality: Monoclonal Clone ID: 4C7H12 Host: Mouse Isotype: Mouse IgG1 Full Product Name: S100B Immunogen: Purified recombinant fragment of human S100B (AA: 1-92) expressed in E. Coli. Storage: 4°C|-20°C for long term storage Formulation: Purified antibody in PBS with 0.05% sodium azide Molecular Weight (Da): 10.7kDa UniProt Accession: P04271 Synonyms: NEF, S100, S100-B, S100beta Research Use Only