S12A3 Rabbit Polyclonal Antibody - RA29611

S12A3 Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29611-50, RA29611-100 Citations, Manuals and MSDS Available upon request. Background: This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: WB 1：500-2000 Applications: WB Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 6559 SWISS: P55017 Source: Rabbit Research Use Only