Product Description

SAE2/UBA2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91200-50, BS91200-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UBT2(Human) Q9Z1F9(Mouse)

Host: Rabbit

Reactivity: Human

Applications: WB IP

All Applications: WB: 1:500
IP:1:10-1:50

Background: The small ubiquitin-related modifier protein SUMO-1 belongs to the ubiquitin-like protein family, which are synthesized as precursor proteins that undergo processing before conjugation to target proteins. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processes, including nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO-1 utilizes homologues of the E1 and E2 enzymes for conjugation to proteins, which include IkBα, MDM2, p53, PML, and RanGap1. AOS1 is homologous to the N-terminal half of E1 and UBA2 is homologous to the C-terminal half of E1. These proteins form a heterodimer that activates SUMO-1.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of GAB2 pAb at 1:500 dilution
Lane 1:MCF-7 whole cell lysate (40ug)
Lane 2:H1792 whole cell lysate (40ug)
Lane 3:A549 whole cell lysate (40ug)

Bioworld Molecular Weight: ~ 80 kDa

Specificity: SAE2/UBA2 polyclonal antibody detects endogenous levels of SAE2/UBA2 protein.

Alternative Name: UBA2, SAE2, UBLE1B, HRIHFB2115, Anthracycline associated resistance ARX, Anthracycline-associated resistance ARX, ARX, FLJ13058, HRIHFB2115, SAE 2, SAE2, SAE2, SUMO 1 activating enzyme subunit 2, SUMO activating enzyme subunit 2, SUMO-activating enzyme subunit 2, UBA2, UBA2 ubiquitin activating enzyme E1 homolog, Ubiquitin like 1 activating enzyme E1B, Ubiquitin like modifier activating enzyme 2, Ubiquitin-like 1-activating enzyme E1B, UBLE1B,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified